COVID-19 has affected nearly every aspect of life—from short- and long-term health problems to how students attend school to the availability of milk in the grocery store. In this book, Scientific American explores how COVID has changed the world over the past two years: how it has disrupted society, accelerated research, and amplified the need for science and humanity. We look at endeavors that have been directly and dramatically transformed, such as disease testing and vaccine development, as well as some of the more unexpected impacts, such as on climate conferences and rocket launches.