The book presents a comprehensive and up-to-date overview of phyhemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phyonstituents from natural products. As such, the book provides an in-depth understanding of phyhemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phyhemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phyhemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phyhemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phyhemicals in cancer.