In Terrorists Meet Professor Grimes, the Professor defeated the terrorists when they took over the airliner on which he and his family were passengers bound for Rome. He and his son got the airliner back to JFK. Now, in this sequel, the terrorists are back, planning to unleash a river of American blood. They also plan to kill Professor Grimes' entire family, starting with his granddaughter. Will the Professor learn of the plot before it is too late? The FBI and CIA are working to prevent the river of blood, but who will protect the Professor's family?